Head of Operations for the Cloud Awards, James Williams, said: "Backbone PLM is a clear example of an organization using innovative technologies to achieve excellence - and most importantly, provide value to its clients. In 2021, Backbone reached a 96 percent customer satisfaction score and a 90 percent customer retention rate with its design-led product development platform.Īccording to Backbone CEO, Jeff Fedor, the organization is "rooted in domain expertise and constantly looking for ways to improve system processes for each one of our brand customers." Providing a centralized, easy-to-use system for consumer goods brands and the Direct to Consumer (D2C) market, Backbone houses product, component, design, and production data for fashion, apparel, footwear, outdoor, home goods, and accessories companies.īackbone's practical approach to innovation has propelled its user growth. This year's award features Backbone in the Best Software as a Service (SMB) category.īackbone PLM is a cloud-based product lifecycle management (PLM) platform that empowers brands to make products smarter, faster, and at scale. The Cloud Awards recognizes organizations, such as Backbone, that have broken ground in their industry to provide an innovative product or service that improves customer growth, development, communication, and financial stability. The 10th annual Cloud Awards seeks to identify, promote, and celebrate innovation in cloud computing and transformative business practices, welcoming global entrants from organizations of any scale. Backbone PLM announced its nomination as a finalist in the international cloud computing awards program: The Cloud Awards.
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In terms of cellular potency, ontogenesis is considered a one-way street with a continuous loss of potency from the totipotent zygote (and very early blastomere stages) to pluripotent ICM and then to less potent cells (multi-, di- and unipotent cells). With further improvements, such as the reduction of heterogeneity in TPS cells as well as optimizing the induction protocol to guide the precise self-differentiation and organization capability of TPS cells during the formation of blastoids, TPS cells might be able to reconstitute a fully functional synthetic embryo in the future.The first successful isolation and maintenance of ES derived from the inner cell mass (ICM) of murine blastocyst stages was described in 1981, 2 and since then acted as game changer for genetic studies in this mammalian model organism. Although the current TPS cells are not capable of generating fully functional blastoids, TPS-blastoids seem to outperform previous attempts and generate cell lineages very close to those in the blastocyst. presents a valuable resource that can potentially be applied in human or other mammalian species for totipotency capture and has a broad application in regenerative medicine. 6, 7 We envision that the study by Xu et al. Recently, two studies reported the existence of a small subpopulation of 8-cell-like cells in cultured naïve human PSCs, which can be enhanced by epigenetic modulation. Taken together, these observations suggest that TPS cells have the potential to differentiate into both embryonic and extraembryonic lineages both in vitro and in vivo.īeyond the mouse, in vitro capture of human 2- or 8-cell-like cell type has attracted a lot of interest for years. TPS-blastoids were able to implant and induce decidualization after transferring into a surrogate. It is worthy of mentioning, compared to EPS-blastoids, 5 EPS-converted TPS-blastoids contain much fewer intermediate cells, which further confirms the superior potency of TPS cells on lineage differentiation. Moreover, by comparing with blastoids generated by other methods, the author found that trophectoderm cells in TPS-blastoids resemble preimplantation trophectoderm in blastocyst instead of postimplantation extraembryonic ectoderm. Single-cell RNA-seq data showed that the TPS-blastoid cells cluster well with the respective cell lineages from blastocysts. To further investigate the potential of TPS cells, the authors attempted the formation of blastocyst-like structures (blastoids) from TPS cells and successfully generated blastoids with both epiblast and trophectoderm markers expression. The author substantiated this finding by ruling out the possibility of having artificially fused cells of TPS cells and host cells in the placenta using differentially labeled host and injected TPS cells. Marker expression and single-cell RNA-seq analysis at early (E10.5) and late (E17.5) stages revealed a high contribution of TPS cells in the placenta. The resulting chimeric embryos showed germline contribution of TPS cells and the presence of TPS-derived trophoblast and visceral endoderm cells. For this, the authors designed and performed chimera formation assays with multiple cells or more stringently, just as a single cell injected into 8-cell embryos. To further substantiate their claims in vivo, the authors examined whether TPS cells have an unbiased ability to contribute to both embryonic and extraembryonic lineage development. Importantly, the cocktail can be successfully employed to derive totipotent-like cells directly from 2-cell mouse embryos without any adaption step. Besides several molecular totipotent features, CPEC-converted cells are also capable of differentiating into extraembryonic cells in vitro. 3 The finding that the CPEC condition as a whole supports totipotency is interesting and novel. Interestingly, RA signaling was recently identified as a critical regulator of totipotency, 4 and DOT1L inhibition was also used in another study as a component for sustaining totipotency in vitro. A condition containing CD1530 (a RARγ agonist), V PA (an HDAC inhibitor), EPZ004777 (a DOT1L inhibitor) and CHIR99021 (a WNT agonist) (collectively, the CPEC condition) turns out to largely and stably induce and maintain cells preserving the totipotent molecular features with intense expression of totipotency markers. 3 performed a chemical screen in extended pluripotent stem (EPS) cells and identified chemicals that can significantly increase 2-cell marker (MERVL-tdTomato/Zscan4-GFP) expression and positive subpopulation. In June issue of Cell Research, Xu et al. While Goodman adds: 'The brain favors symmetry as it interprets it as safe, stable, and calm. Nightstands also provide a great opportunity to personalize your space with lamps, plants, and accessories.' 'In Feng Shui, the Chinese geomancy that aims to harmonize individuals to their surrounding environment, the bedroom carries a heavy symbolic weight. You'll need space on both sides of the bed for a nightstand to ensure symmetry in the room. 'You need to make sure that your bed compliments your room, rather than compromises it,' says Kate Windleton, a feng shui enthusiast and relocation manager at Strong Move. to create an equal and uniform environment for both of you. So that means two pillows on each side, a lampshade on each bedside cabinet, etc. Whatever you do on your end should be mimicked on your partner's side too. Promote calm in your sleep space by adding homewares in pairs and creating equilibrium on both 'sides' of the room. Some consultants have even warned against keeping cacti and Golden Pothos in the home. Nonetheless, not all plants promote good feng shui. Alternatively, there are many plants that exude vibes of love - from the String of Hearts to Anthuriums (all available on Amazon) and would be great as a romantic bedroom idea. To support your health place a small orchid plant on the bedside table in the corner diagonally opposite the bedroom door.' says Sher.Īesthetically, Orchidaceae add such an elegant touch to the bedroom, and caring for orchids is easier than you might think. 'Fresh flowers uplift the energy of a space and bring a strong healing spirit as well as luck and blessings. Studies have also shown that the presence of plants can reduce anxiety levels.' suggests Selfstore.Įven just adding fresh flowers can enhance your sleep space. 'Plants are hugely important for feng shui, they bring nature into your home and allow a room to breathe. Here, the experts share the benefits of houseplants and why you should dot a few around your sleep space. It's clear that indoor plants are a must for good balance, especially when feng shui is all about creating harmony in your surroundings by better connecting you with nature. So if you're feeling inspired by Allen, we've got dreamy blue bedroom ideas, as well as ideas for a green bedroom too. If you're looking to add a splash of color, soft pastel hues such as pale blues, sage greens, pale pinks, and lavenders will create a relaxing, sanctuary and evoke healing energy.' The right shades will promote harmony and a sense of wellbeing, and so considering how these colors make you feel and impact your mood, is key. She says: 'To bring the best feng shui energy to the bedroom, you should, first of all, consider the color of the walls. Helen Shaw, director, Benjamin Moore concurs. 'Psychologically, when we look at these two colors, it creates electronic waves in our brains to feel more settled, and healed or calm.' Bright bold shades such as red or neon colors can over-activate the energy and cause unrest.'ĭon't overdo the amount of color you use either – 'the bedroom is a place of rest and therefore two of the best colors to use are blue and green.' explains Feng Shui expert Marites Allen. 'Pastels and neutral colors are soothing for the mind. 'Paint the walls a peaceful color,' suggests Sher. Invest in a headboard for supportĬhoosing a calm and neutral bedroom color scheme is the best way to create serene surroundings in your space. This will create accessibility as one won’t be climbing on top of the other to get out.' 3. To avoid you and your partner feeling trapped, make sure the bed is placed in the center rather than the corner of the room. When discussing bedroom ideas for couples, Olly Canver, resident manager at Essential Living also adds: 'The bed is the heart of the bedroom, and it’s therefore important to ensure it is placed in the correct position. This will centralize the energy of your room and prevent it from escaping.' You do want your bed to be central to a wall, however, you don't want it to be in line with, or even very close to the door as it's said that your energy will constantly be pulled throughout the night.A little spooky, but, food for thought.Īccording to Adams Selfstore, you should 'Place your bed in the center of the room and not in line with the door. The positioning of your bed is a crucial part of feng shui and there are a couple of dos and don'ts to consider. Alternatively, motorists can use 9th Street to Mountain Avenue to access the WB I-10 on-ramp at Mountain Avenue. Motorists can access the WB I-10 loop on-ramp at Euclid Avenue via a new extended left-turn only lane approaching 8th Street to 7th Street – lanes are shifted to the west to create this new left-turn only lane. On Sunday, May 22 at 9:00 p.m., the westbound (WB) I-10 on-ramp from southbound (SB) Euclid Avenue closed. EB I-10 approaching Monte Vista Avenue to 4th Streetįor more information, please read the Lane Configuration Notice.WB I-10 approaching Euclid Avenue to Central Avenue.The new configurations began in early August at the following locations: To improve the driver experience, there is enhanced lane striping in these areas. This configuration is needed to ad vance construction, install toll equipment, and provide safe, dedicated work zones. Westbound and Eastbound I-10 Lane Configuration ChangesĪs construction continues on the SB Express Lanes, the I-10 freeway lanes were reconfigured in select areas on the westbound and eastbound freeway. Click here Interactive project map to learn more about the bridges. The lanes will be available to HOV 3+ vehicles at a discount, In addition, lanes to assist drivers getting on and off the freeway (auxiliary lanes) are being constructed in selected locations.Įighteen bridges throughout the corridor will either be replaced, widened, or improved to accommodate the widening of the freeway. The third and final future phase of 12 miles will be from Pepper Avenue to Ford Street in Redlands.įor the Phase 1 project, a single new lane is being constructed and combined with the existing HOV lane to provide two tolled express lanes in each direction. The second phase, stretching 11.1 miles from I-15 to Pepper Avenue in Colton, is in design and the final funding components are being sought to enable construction to begin in 2024. The first phase, stretching 10 miles from the Los Angeles County line to I-15, is currently under construction. The eastbound 10 Euclid Avenue off-ramp also will be closed with detour routes posted.SBCTA’s Interstate 10 Corridor Project is comprised of three phases of improvements to benefit the movement of both people and goods on this facility that is important to both San Bernardino County residents and to the local and national economy. 2, at 5 a.m., two right lanes will be closed on the eastbound 10 approaching the eastbound Euclid Avenue off-ramp in Ontario for about 1/4 mile. Detour routes will be posted.īeginning Friday, Sept. The eastbound 10 Freeway’s Monte Vista Avenue on-ramp and westbound Monte Vista Avenue on- and off-ramps also will be closed. 18, at 5 a.m., Monte Vista Avenue in Montclair under the 10 is scheduled to close for work. The westbound 10 Freeway Euclid Avenue loop on-ramp is set to close Tuesday, Sept. The off-ramp will stay closed until Friday, Sept. 12, when the eastbound 10 Freeway’s Euclid Avenue off-ramp in Ontario closed at 6 a.m. Construction on the Express Lanes project is about 75% complete, according to the San Bernardino County Transportation Authority.Ĭlosures began Tuesday, Sept. Work on the 10 Freeway is making way for the addition of toll lanes. Drivers on the 10 Freeway between Montclair and Ontario can expect more closures over the next two weeks as construction continues on the I-10 Express Lanes project. To view the changes made see this link as well. There has since been a number of firmware updates. The above link shows modes in firmware version 2.5.067. You can read more about these modes in our blog post here. Weighing mode, dual display mode, three auto-start modes, and auto-tare mode. The scale will also display a previous stable weight that captures the coffee weight of the shot when you unloaded the cup. It has a resolution of 0.1 grams which is perfect for my 18 g basket. Designed for espresso machine drip trays, the Acaia Lunar Espresso Scale is aesthetically functional for your weighing needs. In all auto start modes, the timer will stop when a negative weight (i.e. This scale is a great tool for improving espresso shot consistency. In all auto start modes, if you do not operate the scale for 30 seconds, it will reset the timer and zero the scale
This option adjusts how quickly the game moves in between the parts where you actually play the game. The options are Broadcast, Fast Play, and Hybrid. First is the presentation mode, which can be found under the presentation settings menu. There are a few other miscellaneous settings you will want to adjust, based on the baseball experience you are looking for. The fisheye and strike zone camera options will focus on the strike zone, even if it is a less cinematic experience. While the accuracy of your pitches is more about your pinpoint movements, you can adjust the camera to zoom in on the strike zone while pitching, to make it easier to place pitches exactly where you want them. On the mound, the default is usually the broadcast camera, which is behind the pitcher's back. Using the fisheye or strike zone options will reduce how much of the batter you can see and focus on the strike zone, which is where you should be looking when trying to hit a pitch. The batting option default depends on which overall playstyle you selected, but there are a few options that will make the strike zone bigger on screen. The batting option has a bigger impact than the pitching camera option but both can be adjusted. Pick the camera angle that best fits your playstyleĪnother setting that makes a big difference in how well you play is the camera angle option. This will give you a tailored experience that matches your own skill level, even as you get better at the game. The downside is that it starts at Beginner, which is likely too easy for most players, but the game will quickly bump up the difficulty as you play, provided you prove yourself ready. Dynamic will increase or decrease in difficulty as you play the game in order to best match your skill level. For new players or players who have taken some time off from the series, the best difficulty option to pick is Dynamic. For players who play the game every year, you likely know what difficulty you like to play on, likely in the All-Star and Hall of Fame region. MLB The Show 22 has nine different difficulty levels to choose from and the difficulty settings can be set for hitting and pitching independently. Now Playing: 23 Minutes of MLB The Show 22 4K Gameplay Set the appropriate difficulty for pitching and hitting These can be changed at any time, so change the controls if you don't like how something feels.īy clicking 'enter', you agree to GameSpot's Depending on the type of experience you want out of the game, you will need to pick the control scheme you like. For example, Pinpoint pitching is the most complicated way to throw pitches in MLB The Show 22, but it also lets you throw with the most precision. We have guides for picking the best pitching, hitting, and baserunning control options, but the important thing to know is that having more control over your players will make you more competitive, especially online. Select the best control schemes for your playstyleįirst things first, you will need to select the control schemes for the different parts of the game. Since the number of options can be overwhelming, especially for new players, here is what you need to do first. Being a baseball simulation game, MLB The Show 22 has a wide variety of setting options, letting you make the game as serious or arcade-like as you want. Before hitting the field in MLB The Show 22, you will likely want to check out the many setting options available in the game. However, I believe that AI won’t entirely replace a logo designer’s job, it will rather help us, designers, to generate more ideas faster. Using AI tools like MidJourney can be an effective way to streamline your process and help you explore a lot of ideas, and so fast. no text, realistic photo details, shadowsįor the most part, when it comes to logo design you should use some of the above-excluding any text, shadows, and realistic details.Īdditionally, by letting the AI tool know what you don't want, you can help it generate better logo concepts, that are more up to your standards. Otherwise, if you leave it to A.I., it cane make your designs overly complex or cluttered. When working with any AI tool, not only Midjourney, it's important to provide clear guidelines and criteria not only for what you want but also for what you don’t want. Screen printing is often used for the mass production of items like t-shirts, so if you’re planning on starting a new clothing brand-it makes a great choice. It’s usually either the first letter of the company name or the company's initials that have been somehow stylized to create a unique, distinct look & feel. The first example is the lettermark logo a type of logo that uses a stylized letter or multiple letters-here’s a prompt example: a lettermark of letter A, logo, serif font, vector, simple -no realistic details However, you can use it to create letter-mark logos, mascot logos, emblem logos, and basically any type of pictorial mark.Įach type of logo has its own unique advantages and disadvantages, so you’ll need to decide on what type of logo you want. Choose the type of logo you wantįirst of all, you need to decide on what type of logo you want, and again-keep in mind that MidJourney is NOT good with text. Now, let’s dive right into designing logos using Midjourney. Update: Check out this massive collection of styles, genres and artists to use in your Midjourney prompts. Just note that Midjourney is NOT good with text, so you will have to use Illustrator, or Canva, in order to add text or refine your designs.įor that, I recommend you also check out my other article where I describe my logo design process in detail. You can also consume this content in video form on my YT channel: to imitate your favorite designer!Īlso, check out my other article where I describe how to use Midjourney for web design.īefore designing your logo, you might want to define your brand first-check out my other article on how to use ChatGPT for brand strategy development. Table of ContentsĪpart from getting multiple ideas fast, you can refer to specific genres, and techniques and you can even ask the A.I. The reason is simple: A logo that would take human designer hours, if not days to create, can be generated by AI in a few seconds. In the realm of graphic design, artificial intelligence (AI) is revolutionizing the way logos are created. How to write prompts for logo design in MidJourney? They might not be perfect, but it’s a good tool to just get logo ideas, fast and easily. Art platform that can help you generate a wide range of unique and creative logo ideas, and it can do so in a fraction of the time a graphic designer would take. Do you wanna know how to create AI-generated logos? The function encodes a payload that contains the API key and an expiration time, then signs the payload with the API secret using the HS256 hashing algorithm. The code defines a function named generateToken() that uses the PyJWT library to create a token for authentication. The code defines the API key and secret variables to be used later in the program. The code imports necessary libraries − jwt, requests, json, and time. # Create a payload of the token containing API key and expiration time # Create a function to generate a token using the PyJWT library # Replace with your own API key and secret We can install these packages with the help of the command shown below. JSON − The json package in Python is used for encoding and decoding JSON data. Requests − The requests package in Python is used for making HTTP requests to web APIs. JWT − JWT (JSON Web Token) is a compact, URL-safe means of representing claims to be transferred between two parties. Go to the "App Credentials" tab, copy your API key and API secret, and save them.īefore we can move ahead with the code, we need to install the following packages − For the company name, you can enter your name, and then click "Continue". Go to and either sign up or sign in to your Zoom account.Ĭlick on the "Develop" tab and select "Build App".Īgree to Zoom's API License and Terms of Use.Ĭhoose "JWT" as the app type because it is easy to use.Įnter the name of your app and click "Create".įill in mandatory details such as your company name, developer's name, and email address. To use the Zoom API, you must first create it by following the steps below − This guide covers how to create a Zoom meeting using Python and Zoom API. In this guide, we will explore how to create a meeting with the Zoom API in Python using the requests library and the Zoom API's authentication mechanisms. In this context, Python provides a simple and efficient way to create meetings through Zoom's API.īy using Python, you can automate the process of creating Zoom meetings and integrate it with other workflows or applications. Zoom provides an API that allows developers to programmatically interact with Zoom's features and functionality, including creating and managing meetings. Zoom is a video conferencing platform that has become increasingly popular for remote meetings and webinars. Glass Globe Options: Standard: Clear Upgrades: 24k Gilded, Silver Leaf, hand-painted Strokes. included/ Clear / E26 Medium Screw Base / 120W total / 1140 Lumens total LED Bulbs upon request. *Disclaimer: Mica Lighting’s products are not manufactured or approved by, or affiliated with, or endorsed by the original designers or manufacturers including Lindsey Adelman. The Original Bubble Chandelier, part of the expertly crafted lighting series, built to order in PELLEs NYC studio since 2008. *Please Note: The original Lindsey Adelman Branching Bubble 5Light Pendant, usually retails for over $5400.00
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